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Polymorphisms associated with response in CD and UC combined (IBD) The polymorphisms generally showed the same direction of effect in both diseases, except for the polymorphisms in LY96 (rs11465996) (Supplementary Tables 1 and 2)

Moreover, polymorphisms in the ARMS2/HTRA1 ( rs10490924 and rs11200638 ) locus are significantly associated with early and late AMD